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61st Annual Meeting of the German Society of Neurosurgery (DGNC) as part of the Neurowoche 2010
Joint Meeting with the Brazilian Society of Neurosurgery on the 20 September 2010

German Society of Neurosurgery (DGNC)

21 - 25 September 2010, Mannheim

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Local field potentials as an intraoperative targeting tool for deep brain stimulation surgery in Parkinson's disease

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  • Florian Grimm - Universitätsklinik für Neurochirurgie, Universitätsklinik Tübingen, Germany
  • Daniel Weiss - Neurologische Universitätsklinik, Universitätsklinik Tübingen, Germany
  • Georgios Naros - Universitätsklinik für Neurochirurgie, Universitätsklinik Tübingen, Germany
  • Sorin Breit - Neurologische Universitätsklinik, Universitätsklinik Tübingen, Germany
  • Tobias Wächter - Neurologische Universitätsklinik, Universitätsklinik Tübingen, Germany
  • Rejko Krüger - Neurologische Universitätsklinik, Universitätsklinik Tübingen, Germany
  • Jeremy Hill - Max-Planck-Institut für biologische Kybernetik Tübingen, Germany
  • Alireza Gharabaghi - Universitätsklinik für Neurochirurgie, Universitätsklinik Tübingen, Germany

Deutsche Gesellschaft für Neurochirurgie. 61. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC) im Rahmen der Neurowoche 2010. Mannheim, 21.-25.09.2010. Düsseldorf: German Medical Science GMS Publishing House; 2010. DocP1886

doi: 10.3205/10dgnc357, urn:nbn:de:0183-10dgnc3579

Published: September 16, 2010

© 2010 Grimm et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Objective: Extraoperative studies of local field potentials (LFP) activity in the subthalamic nucleus (STN) of Parkinson's disease (PD) patients suggest that exaggerated beta band oscillatory activity is a typical pathological correlate for the neurological impairment of these patients. We investigated the possibility of using intraoperative LFPs as a method to specify regions within the STN during deep brain stimulation (DBS) surgery.

Methods: During the course of STN-DBS in 10 awake PD patients both single unit activity and intraoperative LFPs were recorded after overnight withdrawal of dopaminergic medication. A mean of three different trajectories was examined in each case. Electrophysiological data was acquired on a length of 10 mm in the target region followed by a spectral analysis of the LFPs. The borders of the STN were defined by single unit discharge patterns.

Results: In all cases, intraoperative LFPs could be recorded successfully showing a characteristic beta band oscillatory activity within the STN in concordance with the nucleus position indicated by single unit activity. The highest power increase of the beta band was found within a circumscribed region of each individual STN defined by the trajectory and depth of the electrode position.

Conclusions: LFPs are a potentially powerful tool for intraoperative targeting in STN-DBS surgery by providing pathologically specific and complimentary information to single unit discharge characteristics.