Article
Ocular mediators of inflammation and neovascularization in retinal vein occlusion and diabetic retinopathy
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Published: | September 21, 2010 |
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Background: Vitreous samples from patients with retinal vein occlusion showed changes in the concentration of the proteins CCL7, PPBP, CXCL11, ADIPOQ, OPG, TNFRSF18, IL18BP, and VEGFA165b compared to the control group (macular hole, macular pucker). This raised the questions whether these proteins are expressed in ocular tissue and whether they are characteristic of vein occlusion.
Methods: The expression patterns were investigated by immunohistochemistry on specimens with diagnosis for retinal vein occlusion or diabetic retinopathy.
Results: The proteins CCL7, CXCL11, ADIPOQ, OPG, IL18BP, and VEGFA165b were produced by different cells in ocular tissue. In contrast, PPBP and TNFRSF18 were detected in serum only. Obviously, they are expressed anywhere else and transported to the eye in a second step. No differences between eyes from patients with retinal vein occlusion or diabetic retinopathy were found.
Conclusion: The investigated proteins are general mediators of inflammation and neovascularization. Predominantly, they are produced by ocular tissues indicating local inflammation. They are not specific for retinal vein occlusion, although they are expressed at higher levels in this condition.