Article
Comparison of physical capacity on short and long term cardiac transplantation
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Authors
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Guilherme Veiga Guimaraes
- Heart Institute - HCFMUSP, Sao Paulo, Brazil
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Rita Venancio
- LAtiS - CEPEUSP, Sao Paulo, Brazil
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Iram Teixeira
- LAtiS - CEPEUSP, Sao Paulo, Brazil
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Lucas Pascoaline
- LAtiS - CEPEUSP, Sao Paulo, Brazil
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Aline Tavares
- LAtiS - CEPEUSP, Sao Paulo, Brazil
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Vitor Carvalho
- InCor - FMUSP, Sao Paulo, Brazil
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Osvaldemir Rodrigues
- LAtiS - CEPEUSP, Sao Paulo, Brazil
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Edimar Bocchi
- InCor - FMUSP, Sao Paulo, Brazil
| Published: | October 24, 2011 |
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Outline
Text
Objective: Cardiac transplant is the last alternative therapy for patients suffering from end stage heart failure. It aims to manage these patients to have bigger hemodynamic improvement and better quality of life. Although functional capacity is caught up post-cardiac transplant (TX), some physiological responses remain reduced and become even more decrease with the use of medicaments. Nevertheless, there are few trials comparing people at different post-cardiac transplant terms according to their cardiorespiratory responses. This paper aims to evaluate and compare cardiorespiratory data of people at different post-cardiac transplant terms.
Material/Methods: 21 post-Tx patients (8 women) were divided into two groups according to their Tx- term. G1 was defined as long-term Tx, with ≥6 years post-Tx, n=10, age of 51.5±14.6 years, BMI 28.3±11.2 kg/m2 and LVEF 62.7±3.5 %; G2 as short-term Tx, with ≤ 3 years post-Tx, n=11, age of 41±15.2 years, BMI 25.3±4.7 kg/m2 and LVEF 67±4.4 %. All patients were submitted to a cardiorespiratory test performed on a treadmill. Their hemodynamic data, heart rate (HR), systolic and diastolic blood pressure (SBP and DBP) were evaluated at rest, peak exercise and recovery, and, the cardiorespiratory one, at peak exercise.
Results: Hemodynamic data showed no significant difference between G1 and G2 respectively, with HR at rest (beats/min) 93.9±7.1 vs. 97±11, HR at peak exercise (beats/min) 130.6±13.5 vs. 128.4±19; SBP at rest (mmHg) 130.2±24.8 vs. 122.7±1.3; SBP at peak exercise (mmHg) 155.6±29.4 vs. 146±35.4; SBP at 1st min of recovery (mmHg) 154.2±32.5 vs. 143.7±28.9; DBP at rest (mmHg) 86.9±12 vs. 84.2±8.6; DBP at exercise peak (mmHg) 75.1±14.6 vs. 70.3±12.8; and DBP at 1st min of recovery (mmHg) 80.9±11.7 vs. 74.8±10. No significant difference was also observed between G1 and G2 for exercise test duration (min): 13.3±3.4 vs. 14.2±3.1 and for cardiorespiratory data: peak VO2:(ml/Kg/min) 21.4±3.4 vs. 22.9±4.4; slope VE/VCO2: 28.6±4.0 vs. 28.6±3.2 and VE: (L/min) 33.7±4.4 vs. 35.1±2.3.
Conclusion: Neither short nor long term transplantation has influence on physical capacity of cardiac recipients.
References
- 1.
- Carvalho VO, Bocchi EA, Guimarães GV. Aerobic Exercise Prescription in Adult Heart Transplant Recipients: A Review. Cardiovasc Ther. 2010 [Epub ahead of print].
- 2.
- Guimarães GV, D'Avila V, Bocchi EA, Carvalho VO.Norepinephrine remains increased in the six-minute walking test after heart transplantation. Clinics (Sao Paulo). 2010;65(6):587-91.
- 3.
- Chaudry H, Yip DS, Bush T, Reynolds V, Witzke L, Taylor V, Hosenpud JD. Exercise performance increases coincident to body weight over the first two years following cardiac transplantation. Clin Transplant. 2011. DOI: 10.1111/j.1399-0012.2011.01410.x. [Epub ahead of print]
