Article
Intravitreous injection of bevacizumab in radiation maculopathy after brachytherapy of malignant melanoma
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Published: | June 15, 2011 |
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Outline
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Purpose: To investigate the benefit of bevacizumab in radiation retinopathy, which is a common sight-threatening complication of brachytherapy for malignant melanoma.
Methods: In this retrospective study we included 9 consecutive patients who developed macular edema after brachytherapy and were followed up 3 months after triple intravitreal injection of bevacizumab. Best corrected visual acuity (BCVA), biomicroscopic indirect fundus examination and OCT findings were evaluated.
Results: The mean pre-treatment visual acuity was 0.15 (standard deviation [SD]±0.12), the mean central macular thickness (CMT) measured in OCT was 560 µm (SD±133.9 µm). After 3 months the mean visual acuity was 0.2 (SD±0.22), CMT 453 µm (SD±101 µm). Stabilization (0±2 lines) or improvement of BCVA was obtained in 7 eyes.
Discussion: From our retrospective pilot study, there is strong indication that bevacizumab is able to stabilize visual acuity in macular edema in radiation retinopathy.