Article
Hyperreflectivity on spectral domain optical coherence tomography in macular telangiectasia type 2
Search Medline for
Authors
Published: | June 15, 2011 |
---|
Outline
Text
Purpose: To investigate tissue optical properties in retinal layers of patients diagnosed with type 2 idiopathic macular telangiectasia (MacTel type 2) using spectral domain optical coherence tomography (SD OCT).
Methods: Forty three patients diagnosed with MacTel type 2 and 15 age-matched controls were enrolled in a cross-sectional case-control study. Tomographic SD-OCT and topographic scanning laser ophthalmoscope (SLO) images were simultaneously recorded (Spectralis HRA+OCT, Heidelberg Engineering, Germany). A low contrast setting was used to enhance the visualization of focal differences in tissue optical properties in the high-amplitude backscatter signal range.
Results: Higher tissue optical properties were detected in the neurosensory retina of MacTel type 2 patients using the SD OCT compared to the control group. This hyperreflectivity was most prominent in the outer plexiform layer, the inner plexiform layer and the nerve fibre layer and focal in the ganglion cell layer, the inner nuclear layer and the outer nuclear layer. The phenomenon was confined to the parafoveolar region. It was present in angiographically apparently unaffected areas. The phenomenon decreased or disappeared after the intravitral injection of ranibizumab in 10 patients.
Conclusions: The SD OCT detected an active disease process before MacTel type 2 manifested by classical angiographic signs, which may help to indentify early disease stages and affected family members. We suggest this phenomenon to represent early edema in the inner retinal layers.