Article
Neuroprotective effect of erythropoietin
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Published: | September 11, 2012 |
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Erytropoietin (EPO) is a hematopoitic factor which regulates committed lineage-specific progenitor. EPO and its receptor are expressed in the human brain tissues. EPO is neuroprotective not only cerebral ischemia but excite toxin and neuroinflammation. Whether EPO protects spinal motor neuron death against glutamate and axotomy induced spinal motor neuron death in the spinal motor neurons. EPO prevented not only glutamate- but also axotomy-induced neuronal death in the spinal motor neusons. There are no relationship between dose of EPO and protective effects in both studies. Amyotrophic lateral sclerosis (ALS) is characterized by death of spinal motor eurons and our results show that EPO may be one of candidate of therapeutic strategy in ALS. Further study in EPO with ALS is needed.