Article
Multiple small branch-duct IPMN in imaging in familial pancreatic cancer – Indicator for concomitant high grade pancreatic intraepithelial neoplasia?
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Published: | March 21, 2014 |
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Introduction: Screening programs for familial pancreatic cancer (FPC) are currently based on endoscopic ultrasonography and / or magnetic resonance imaging. In up to 40% of individuals at risk, cystic lesions are detected, which are suspicious for small intraductal papillary mucinous neoplasms of the branch ducts (BD-IPMN). The pathological importance of these lesions in the setting of FPC is yet unknown.
Material and methods: Individuals at risk from a prospective screening program for familial pancreatic cancer with small "imaging" IPMNs of the branch-duct type (BD-IPMN), who underwent pancreatic resection, were analysed regarding clinico-pathological data and the locations of pancreatic lesions.
Results: In the last 10 years (2002-2012) 172 individuals at risk out of 60 FPC families took part in the screening program. Twelve of these individuals at risk had multiple small (2-10mm) unicystic lesions or multicystic lesions in the pancreatic body and tails suspicious for BD-IPMNs upon MRI imaging. After interdisciplinary counselling, 7 individuals decided to undergo pancreatic resection (6x total pancreatectomy, 1x PPPD), although none fulfilled the consensus criteria for IPMN resection.Histological examination revealed BD-IPMNs with low or moderate dysplasia of the gastric type in combination with multifocal PanIN2 and PanIN3 lesions in 6 individuals. One patient had only tiny ductectasias in the pancreatic tail with multifocal PanIN2 lesions in the entire gland and one PanIN3 lesion in the pancreatic head. Surprisingly, the location of the most dysplastic histological lesions did not correspond to the preoperatively detected lesions and were not visible in preoperative imaging.
Conclusion: In the setting of FPC, the presence of multiple small BD-IPMN in imaging may indicate the presence of high-grade PanIN lesions elsewhere in he pancreas.