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85th Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

28.05. - 01.06.2014, Dortmund

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Successful treatment of rhino-orbital-cerebral mucormycosis. Case report

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German Society of Oto-Rhino-Laryngology, Head and Neck Surgery. 85th Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery. Dortmund, 28.05.-01.06.2014. Düsseldorf: German Medical Science GMS Publishing House; 2014. Doc14hno16

doi: 10.3205/14hno16, urn:nbn:de:0183-14hno160

Published: July 24, 2014

© 2014 Scheenstra et al.
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A 19-year-old boy with severe aplastic anemia e.c.i., was diagnosed with Rhizopus oryzae (mucormycosis) in the frontal sinus. As a very aggressive and often mutilating disease, rhino-orbital-cerebral mucormycosis is notorious for its poor prognosis with up to almost 100% mortality.

We present a patient with successful treatment and excellent aesthetic result. The success of the treatment was to our opinion rapid diagnosis and long-term systemic treatment with Amphotericin B, in combination with the intensive local therapy. This local therapy consisted of nasendoscopically guided rinsing with 5 cc Amphotericin B dissolved in 20 cc NaCl, combined with multiple endoscopic sinus surgery (including Draf2A with places endonasal drains, Draf 3, revision Draf3 with external frontalis drains) in order to obtain optimal drainage of the frontal sinus.