This monograph deals with the possibilities of ergonomics implementation in business logistics with the aim to provide sustainable competitiveness of enterprises via effective human work in ergonomically acceptable and flexible conditions. For the purposes of the current monograph, business logistics is studied on the level of logistic operations involving all employees who perform work activities directly initiating disorders and damages to the musculoskeletal system. The monograph analyses the methodology of ergonomics implementation in business logistics through the improvement of work activities and reducing employees’ stress. In the above-mentioned methodology, an employee represents both, an object and a subject of all efforts building the work environment. This includes supporting the sustainable quality of employees’ work life while simultaneously considering both environmental and economic conditions.